DR. COLIN DAWES
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I am currently a Professor Emeritus in the Department of Oral Biology at the University of Manitoba. My research has primarily been on identifying the normal physiological variables which can influence the flow rate and composition of saliva. I have developed a well-accepted model of oral sugar clearance and identified the important factors influencing this. I have also shown that saliva is present in the mouth as a very thin film, less than 0.1 mm in thickness. We have modelled the diffusion of sugar into dental plaque and its conversion to acid and shown the critical importance of the velocity of the salivary film in removing the acid after exposure to fermentable carbohydrate. More recently, I have been a member of an international group for the World Workshop on Oral Medicine VI, tasked with reviewing the causes and treatment of salivary dysfunction.
The following are recent publications: Dawes C (2014). Invited commentary on an article by Poon et al. Reduction in unstimulated salivary flow rate in burning mouth syndrome. Brit Dent J 217:364-5.
Jentzen W, Richter M, Nagarajah J, Poeppep TD, Brandau W, Dawes C, Bockisch A, Binse I (2014) Chewing gum stimulation did not reduce the absorbed dose to salivary glands during radioiodine treatment of thyroid cancer as inferred from pre-therapy 124I PET/CT imaging. Eur J Nucl Med Mol Imaging Physics 1:100 (06 Dec 2014).
Aliko A, Wolff A, Dawes C, Aframiam D, Procter GB, Ekstöm J, Narayana N, Villa A, Sia YW, Joshi RK, McGowan R, Jensen SB, Kerr A, Pedersen AML, Vissink A. (2015) World Workshop on Oral Medicine VI: Clinical implications of medication-induced salivary gland dysfunction. Oral Surg Oral Med Oral Pathol Oral Radiol 120:185-206.
Dawes C, Pedersen AML, Villa A, Ekström J, Proctor GB, Vissink A, Aframian D, McGowan R, Aliko A, Narayana N, Sia YW, Joshi RK, Jensen SB, Kerr AR, Wolff A. (2015) The functions of saliva: a review sponsored by the World Workshop on Oral Medicine VI. Arch Oral Biol 60:863-874.
Villa A, Wolff A, Aframian D, Vissink A, Ekström J, Proctor GB, McGowan R, Narayana N, Aliko A, Sia YW, Joshi RK, Jensen SB, Kerr AR, Dawes C, Pedersen AML. (2015) World Workshop on Oral Medicine VI: A systematic review of medication-induced salivary gland dysfunction: prevalence, diagnosis and treatment. Clin Oral Invest (In press) Doi 10.1007/s00784-015-1488-2.
Villa A, Wolff A, Nagamani N, Dawes C, Aframian D, Pedersen AML, Vissink A, Aliko A, Sia YW, Joshi RK, McGowan R, Jensen SB, Kerr A, Ekström J, Proctor G. (2016) World Workshop on Oral Medicine VI: A systematic review of medication-induced salivary gland dysfunction. Oral Dis 22:365-382. Helmerhorst EJ, Dawes C, Oppenheim FG. (2018). The complexity of oral physiology and its impact on salivary diagnostics. Oral Diseases 24:363-371. doi: 10.1111/odi.12780. Dawes C, Wong DWT. (2019). Role of saliva and salivary diagnostics in the advancement of oral health. J Dent Res. 98:133-141. The following resources are available to share with other institutions or laboratories. There may be fees associated with the use of these resources. Please contact the researcher to discuss necessary arrangements.
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